Correction: CleavPredict: A Platform for Reasoning about Matrix Metalloproteinases Proteolytic Events
نویسندگان
چکیده
In the Funding statement, the name of the second funder should be “Russian Foundation for Basic Research.” The correct Funding statement is: “This work was supported by the National Institutes of Health (NIH) grant R01GM098835 (PC) and by the Russian Foundation for Basic Research grant: 15-04-06861a and Russian Academy of Sciences via program "Molecular and Cellular Biology" (MK). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.”
منابع مشابه
CleavPredict: A Platform for Reasoning about Matrix Metalloproteinases Proteolytic Events
CleavPredict (http://cleavpredict.sanfordburnham.org) is a Web server for substrate cleavage prediction for matrix metalloproteinases (MMPs). It is intended as a computational platform aiding the scientific community in reasoning about proteolytic events. CleavPredict offers in silico prediction of cleavage sites specific for 11 human MMPs. The prediction method employs the MMP specific positio...
متن کاملMatrix metalloproteinases in the process of invasion and metastasis of breast cancer
Metastatic cascade in malignant tumors, including breast cancer, starts with localized invasion of the host tissue. This process, requiring that tumor cells separate from each other, includes loss of homotypic and heterotypic cell adhesion and cell-cell contact inhibition, acquisition of motility, exacerbated by “epithelial-to-mesenchymal transition”, and production of proteolytic enzymes which...
متن کاملMethods for Detection of Matrix Metalloproteinases as Biomarkers in Cardiovascular Disease
Matrix metalloproteinases (MMPs) are a family of zinc-dependent proteolytic enzymes that degrade extracellular matrix (ECM) components like collagen, fi bronectin, and laminin. While this activity is important for normal development, morphogenesis, and wound healing, deregulation of MMP activity has been implicated in a number of cardiovascular diseases, including congenital heart defects, athe...
متن کاملRole of matrix metalloproteinases (MMPs) and MMP inhibitors on intracranial aneurysms: a review article
Cerebrovascular disease is one of the leading causes of death in the world, and about one-fourth of cerebrovascular deaths are due to ruptured cerebral aneurysms (CA). Hence it is important to find a way to reduce aneurysm formation and its subsequent morbidity and mortality. Proteolytic activity capable of lysing gelatin has been shown to be increased in aneurysm tissue and expressio...
متن کاملRole of Matrix Metalloproteinases in Atherosclerosis: Pathophysiological and Therapeutic Implications
Atherosclerosis continues to cause considerable morbidity and mortality in the Western countries. In response to cardiovascular risk factors, a cascade of compensatory structural events occurs within the vessel wall. It has become increasingly evident that significant alterations in the structure and composition of the extracellular matrix (ECM) play a key role in the atherogenic process. Far f...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 10 شماره
صفحات -
تاریخ انتشار 2015